Right after losing her father, ten-year-old Annie Zechman gets a visit from her dead grandmother. Even more bad things are coming, and Annie must choose whether they come early or late in life. Annie chooses early, setting her on a tumultuous, coming-of-age journey through the American social landscape of the 60s and 70s.

With help from flute player Fran, sex therapy partner Duncan, biology professor Rickson, art professor Meyer, Nordic soulmate Jonas, roommate Mona, heating pad lover Mitchell, best friend Santos, and a crew of therapists, Annie may make it to thirty, but what will it cost her? Her dreams? Her sanity? Her very self?